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Chronic lymphocytic leukemia

ACOXL · rs17483466

Where this position leads

Condition: Chronic Lymphocytic Leukaemia

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Chronic lymphocytic leukemia — no copies of the reported risk allele.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Chronic lymphocytic leukemia.

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Chronic lymphocytic leukemia compared to the general population.

Source

Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia

Berndt SI, Skibola CF, Joseph V, Camp NJ, Nieters A, Wang Z, Cozen W, Monnereau A, Wang SS, Kelly RS, Lan Q, Teras LR

and 118 more — show all

Chatterjee N, Chung CC, Yeager M, Brooks-Wilson AR, Hartge P, Purdue MP, Birmann BM, Armstrong BK, Cocco P, Zhang Y, Severi G, Zeleniuch-Jacquotte A, Lawrence C, Burdette L, Yuenger J, Hutchinson A, Jacobs KB, Call TG, Shanafelt TD, Novak AJ, Kay NE, Liebow M, Wang AH, Smedby KE, Adami HO, Melbye M, Glimelius B, Chang ET, Glenn M, Curtin K, Cannon-Albright LA, Jones B, Diver WR, Link BK, Weiner GJ, Conde L, Bracci PM, Riby J, Holly EA, Smith MT, Jackson RD, Tinker LF, Benavente Y, Becker N, Boffetta P, Brennan P, Foretova L, Maynadie M, McKay J, Staines A, Rabe KG, Achenbach SJ, Vachon CM, Goldin LR, Strom SS, Lanasa MC, Spector LG, Leis JF, Cunningham JM, Weinberg JB, Morrison VA, Caporaso NE, Norman AD, Linet MS, De Roos AJ, Morton LM, Severson RK, Riboli E, Vineis P, Kaaks R, Trichopoulos D, Masala G, Weiderpass E, Chirlaque MD, Vermeulen RC, Travis RC, Giles GG, Albanes D, Virtamo J, Weinstein S, Clavel J, Zheng T, Holford TR, Offit K, Zelenetz A, Klein RJ, Spinelli JJ, Bertrand KA, Laden F, Giovannucci E, Kraft P, Kricker A, Turner J, Vajdic CM, Ennas MG, Ferri GM, Miligi L, Liang L, Sampson J, Crouch S, Park JH, North KE, Cox A, Snowden JA, Wright J, Carracedo A, Lopez-Otin C, Bea S, Salaverria I, Martin-Garcia D, Campo E, Fraumeni JF Jr, de Sanjose S, Hjalgrim H, Cerhan JR, Chanock SJ, Rothman N, Slager SL

Nature genetics · 2013 · PMID 23770605 · open access

Questions about rs17483466

What is rs17483466?

rs17483466 is a single position in the genome, in or near the ACOXL gene. Published research associates it with chronic lymphocytic leukemia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs17483466 linked to?

On MyGeneLog this position is linked to Chronic Lymphocytic Leukaemia. The research behind each link, and its sources, are set out on that condition page.

Does having rs17483466 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs17483466 come from?

GWAS Catalog, Nat Genet 2013, PMID:23770605. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

← See all variants