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Cortical thickness

WNT3A · rs1745416

What the study found

Who was studied 35,657 White British ancestry individuals.

The effect The reported allele is G; the catalogue records no effect size ; p = 4 × 10−11.

How common The G allele had a frequency of about 49% in the people studied.

Where it sits Chromosome 1, band 1q42.13 — in an intron of WNT3A.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Cortical thickness — no copies of the reported risk allele.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Cortical thickness.
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Cortical thickness compared to the general population.
Source

Questions about rs1745416

What is rs1745416?

rs1745416 is a single position in the genome, in or near the WNT3A gene. Published research associates it with cortical thickness. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs1745416 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1745416 come from?

GWAS Catalog, NeuroImage 2021, PMID:34560273. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Cortical thickness (rs1745416). MyGeneLog™. https://www.mygenelog.com/variants/rs1745416

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