MYRF · rs174534
Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 717 Singaporean Chinese ancestry myocardial infarction cases, 644 Singaporean Chinese ancestry controls.
The effect Each copy of the G allele shifted the measure 0.177 lower (95% confidence interval 0.15-0.21); p = 1 × 10−29.
How common The G allele had a frequency of about 67% in the people studied.
Where it sits Chromosome 11, band 11q12.2 — in an intron of TMEM258.
What ClinVar records
Classification
Benign; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 2 submitters), last evaluated 2021-05-13.
ClinVar record 1227305 NM_001127392.3(MYRF):c.3016+162A>G
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs174534 is a single position in the genome, in or near the MYRF gene. Published research associates it with plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Genes Nutr 2015, PMID:26584805. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) (rs174534). MyGeneLog™. https://www.mygenelog.com/variants/rs174534