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Who was studied 6,167 European ancestry Barrett's oesophagus cases, 4,112 European ancestry esophageal adenocarcinoma cases, 17,159 European ancestry controls.
The effect
Each copy of the G allele carried 1.19 times the odds of Barrett's esophagus or Esophageal adenocarcinoma (95% confidence interval 1.12-1.25); p = 5 × 10−10.
Where it sits Chromosome 7, band 7q31.2 — in an intron of CFTR.
What each result means
A/ANo copy of the version the research linked to Barrett's esophagus or Esophageal adenocarcinoma. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Barrett's esophagus or Esophageal adenocarcinoma. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Barrett's esophagus or Esophageal adenocarcinoma. That is the strongest link of the three results. A link in a study is not a diagnosis.
The Lancet. Oncology · 2016 · PMID 27527254 · open access
Questions about rs17451754
What is rs17451754?
rs17451754 is a single position in the genome, in or near the CFTR gene. Published research associates it with barrett's esophagus or esophageal adenocarcinoma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs17451754 linked to?
On MyGeneLog this position is linked to Oesophageal Cancer. The research behind each link, and its sources, are set out on that condition page.
Does rs17451754 affect how medicines work?
CFTR carries pharmacogenomic findings for Elexacaftor/tezacaftor/ivacaftor (Trikafta), Ivacaftor, Vanzacaftor/tezacaftor/deutivacaftor (Alyftrek). That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Does having rs17451754 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs17451754 come from?
GWAS Catalog, Lancet Oncol 2016, PMID:27527254. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
1 44222422228Reads by AI crawlersClaude2ChatGPT2Google · Gemini0Perplexity2Meta AI4Microsoft · Copilot0Amazon2Apple2China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others28Total44Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Barrett's esophagus or Esophageal adenocarcinoma (rs17451754). MyGeneLog™. https://www.mygenelog.com/variants/rs17451754