Gene Knowledge Graph
UTC
Sensitive

Barrett's esophagus or Esophageal adenocarcinoma

CFTR · rs17451754

Where this position leads

Drug: Ivacaftor

rs17451754 Drug: Ivacaftor Ivacaftor Drug rs17451754 rs17451754 CFTR

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Barrett's esophagus or Esophageal adenocarcinoma — no copies of the reported risk allele.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Barrett's esophagus or Esophageal adenocarcinoma.
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Barrett's esophagus or Esophageal adenocarcinoma compared to the general population.
Source
Genome-wide association studies in oesophageal adenocarcinoma and Barrett's oesophagus: a large-scale meta-analysis
Gharahkhani P, Fitzgerald RC, Vaughan TL, Palles C, Gockel I, Tomlinson I, Buas MF, May A, Gerges C, Anders M, Becker J, Kreuser N
and 57 more — show all
Noder T, Venerito M, Veits L, Schmidt T, Manner H, Schmidt C, Hess T, Böhmer AC, Izbicki JR, Hölscher AH, Lang H, Lorenz D, Schumacher B, Hackelsberger A, Mayershofer R, Pech O, Vashist Y, Ott K, Vieth M, Weismüller J, Nöthen MM, Attwood S, Barr H, Chegwidden L, de Caestecker J, Harrison R, Love SB, MacDonald D, Moayyedi P, Prenen H, Watson RGP, Iyer PG, Anderson LA, Bernstein L, Chow WH, Hardie LJ, Lagergren J, Liu G, Risch HA, Wu AH, Ye W, Bird NC, Shaheen NJ, Gammon MD, Corley DA, Caldas C, Moebus S, Knapp M, Peters WHM, Neuhaus H, Rösch T, Ell C, MacGregor S, Pharoah P, Whiteman DC, Jankowski J, Schumacher J
Barrett's and Esophageal Adenocarcinoma Consortium (BEACON) · Esophageal Adenocarcinoma GenEtics Consortium (EAGLE) · Wellcome Trust Case Control Consortium 2 (WTCCC2)
The Lancet. Oncology · 2016 · PMID 27527254 · open access

Questions about rs17451754

What is rs17451754?

rs17451754 is a single position in the genome, in or near the CFTR gene. Published research associates it with barrett's esophagus or esophageal adenocarcinoma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs17451754 affect how medicines work?

CFTR carries pharmacogenomic findings for Ivacaftor. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs17451754 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs17451754 come from?

GWAS Catalog, Lancet Oncol 2016, PMID:27527254. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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