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Who was studied 57,893 European ancestry cases, 1,505,102 European ancestry controls, 7,046 East Asian ancestry cases, 176,756 East Asian ancestry controls, 2,440 Hispanic or Latin American cases, 582,220 Hispanic or Latin American controls, 288 African ancestry cases, 193,985 African ancestry controls.
The effect
The reported allele is A; the catalogue records no effect size
; p = 3 × 10−10.
Where it sits Chromosome 12, band 12q12 — in an intron of LRRK2.
What each result means
A/ATwo copies of the version the research linked to Parkinson's disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Parkinson's disease. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Parkinson's disease. This is the starting point the study compared everyone against.
Nature genetics · 2024 · PMID 38155330 · open access
Questions about rs17443414
What is rs17443414?
rs17443414 is a single position in the genome, in or near the LRRK2 gene. Published research associates it with parkinson's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs17443414 linked to?
On MyGeneLog this position is linked to Parkinson's Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs17443414 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs17443414 come from?
GWAS Catalog, Nature genetics 2024, PMID:38155330. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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