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Triglycerides

LPL · rs17410962

Where this position leads

Strength of the evidence

3 / 4

Its strongest genetic-study result is p = 10⁻⁵⁴, with 10 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 7,601 African American individuals, 3,335 Hispanic individuals; replicated in 7,138 African American individuals.

The effect Each copy of the G allele shifted the measure 0.106 lower; p = 7 × 10⁻⁹.

How common The G allele had a frequency of about 11% in the people studied.

Where it sits Chromosome 8, band 8p21.3 — between genes, 23.3 kb from LPL.

How common each version is

AG

Korean KRGDB

A 12.0% · G 88.0%

Korean Korea4K

A 11.6% · G 88.4%

Japanese ToMMo

A 13.0% · G 87.0%

Vietnamese

A 8.5% · G 91.5%

World gnomAD

A 14.5% · G 85.5%

World 1000 Genomes

A 14.9% · G 85.1%

World TOPMed

A 14.9% · G 85.0%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

A/A No copy of the version the research linked to Triglycerides. This is the starting point the study compared everyone against.

A/G One copy of the version the research linked to Triglycerides. That is a smaller link than two copies.

G/G Two copies of the version the research linked to Triglycerides. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Genome-wide characterization of shared and distinct genetic components that influence blood lipid levels in ethnically diverse human populations

Coram MA, Duan Q, Hoffmann TJ, Thornton T, Knowles JW, Johnson NA, Ochs-Balcom HM, Donlon TA, Martin LW, Eaton CB, Robinson JG, Risch NJ

and 5 more — show all

Zhu X, Kooperberg C, Li Y, Reiner AP, Tang H

American journal of human genetics · 2013 · PMID 23726366

Questions about rs17410962

What is rs17410962?

rs17410962 is a single position in the genome, in or near the LPL gene. Published research associates it with triglycerides. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs17410962 linked to?

On MyGeneLog this position is linked to High Triglycerides. The research behind each link, and its sources, are set out on that condition page.

Does having rs17410962 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs17410962 come from?

GWAS Catalog, Am J Hum Genet 2013, PMID:23726366. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Triglycerides (rs17410962). MyGeneLog™. https://www.mygenelog.com/variants/rs17410962

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