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diastolic blood pressure (DBP, maximum, inv-normal transformed)

MTHFR · rs17375901

Where this position leads

Condition: Blood Pressure

rs17375901 Condition: Blood Pressure Blood Pressure Condition rs17375901 rs17375901 MTHFR

What the study found

Who was studied 119,274 African American or Afro-Caribbean individuals, 57,979 Hispanic or Latin American individuals, 6,421 East Asian ancestry individuals, 425,680 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.0567 higher (95% confidence interval 0.045-0.069); p = 3 × 10−20.

How common The C allele had a frequency of about 95% in the people studied.

Where it sits Chromosome 1, band 1p36.22 — in an intron of MTHFR.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of diastolic blood pressure (DBP, maximum, inv-normal transformed) compared to the general population.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with diastolic blood pressure (DBP, maximum, inv-normal transformed).
T/T Published research associates this genotype with typical/baseline likelihood of diastolic blood pressure (DBP, maximum, inv-normal transformed) — no copies of the reported risk allele.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs17375901

What is rs17375901?

rs17375901 is a single position in the genome, in or near the MTHFR gene. Published research associates it with diastolic blood pressure (dbp, maximum, inv-normal transformed). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs17375901 linked to?

On MyGeneLog this position is linked to Blood Pressure. The research behind each link, and its sources, are set out on that condition page.

Does having rs17375901 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs17375901 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

diastolic blood pressure (DBP, maximum, inv-normal transformed) (rs17375901). MyGeneLog™. https://www.mygenelog.com/variants/rs17375901

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