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Who was studied 3,230 European ancestry cases, 4,829 European ancestry controls; replicated in 1,339 European ancestry trios, 2,325 European ancestry cases, 1,809 European ancestry controls.
The effect
Each copy of the T allele carried 1.18 times the odds of Crohn's disease; p = 7 × 10−9.
How common The T allele had a frequency of about 57% in the people studied.
Where it sits Chromosome 21, band 21q21.1 — between genes, 57.6 kb from CYCSP42.
What each result means
C/CNo copy of the version the research linked to Crohn's disease. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Crohn's disease. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Crohn's disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs1736135 is a single position in the genome, in or near the near CYCSP42 gene. Published research associates it with crohn's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1736135 linked to?
On MyGeneLog this position is linked to Crohn's Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs1736135 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1736135 come from?
GWAS Catalog, Nature genetics 2008, PMID:18587394. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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