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Who was studied 395 European ancestry cases, 1,975 European ancestry controls; replicated in 1,243 European ancestry cases, 4,779 European ancestry controls.
The effect
Each copy of the T allele carried 1.58 times the odds of Sjögren's syndrome (95% confidence interval 1.36–1.84); p = 2 × 10−16.
How common The T allele had a frequency of about 12% in the people studied.
Where it sits Chromosome 7, band 7q32.1 — in an intron of TNPO3.
What each result means
C/CNo copy of the version the research linked to Sjögren's syndrome. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Sjögren's syndrome. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Sjögren's syndrome. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2013 · PMID 24097067 · open access
Questions about rs17339836
What is rs17339836?
rs17339836 is a single position in the genome, in or near the IRF5 gene. Published research associates it with sjögren's syndrome. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs17339836 linked to?
On MyGeneLog this position is linked to Sjögren's Syndrome. The research behind each link, and its sources, are set out on that condition page.
Does having rs17339836 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs17339836 come from?
GWAS Catalog, Nat Genet 2013, PMID:24097067. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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