SMAD3 · rs17293443
Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 1,980 European ancestry mothers of spontaneous dizygotic twins, 12,953 European ancestry controls; replicated in 3,597 Icelandic ancestry mothers of spontaneous dizygotic twins, 297,348 Icelandic ancestry controls.
The effect Each copy of the C allele carried 1.15 times the odds of Spontaneous dizygotic twinning (95% confidence interval 1.07-1.23); p = 6 × 10−11.
How common The C allele had a frequency of about 21% in the people studied.
Where it sits Chromosome 15, band 15q22.33 — in an intron of SMAD3.
rs17293443 is a single position in the genome, in or near the SMAD3 gene. Published research associates it with spontaneous dizygotic twinning. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Am J Hum Genet 2016, PMID:27132594. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Spontaneous dizygotic twinning (rs17293443). MyGeneLog™. https://www.mygenelog.com/variants/rs17293443