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Who was studied 23,021 European ancestry cases, 296,016 European ancestry controls.
The effect
Each copy of the T allele carried 0.92 times the odds of Osteoarthritis (with total hip replacement) (95% confidence interval 0.901546561-0.942747862); p = 9 × 10−13.
How common The T allele had a frequency of about 65% in the people studied.
Where it sits Chromosome 6, band 6p21.1 — in an intron of RUNX2.
What each result means
C/CNo copy of the version the research linked to Osteoarthritis (with total hip replacement). This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Osteoarthritis (with total hip replacement). That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Osteoarthritis (with total hip replacement). That is the strongest link of the three results. A link in a study is not a diagnosis.
rs17288390 is a single position in the genome, in or near the RUNX2 gene. Published research associates it with osteoarthritis (with total hip replacement). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs17288390 linked to?
On MyGeneLog this position is linked to Osteoarthritis. The research behind each link, and its sources, are set out on that condition page.
Does having rs17288390 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs17288390 come from?
GWAS Catalog, Cell 2021, PMID:34450027. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 5122Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others2Total5Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Osteoarthritis (with total hip replacement) (rs17288390). MyGeneLog™. https://www.mygenelog.com/variants/rs17288390