White matter microstructure (tract mean) Anterior limb of internal capsule (L1)
SLC38A5 · rs17281188
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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 37,772 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 6.3 z score lower; p = 3 × 10−10.
Where it sits Chromosome X, band Xp11.23 — a missense change in SLC38A5.
What each result means
A/ATwo copies of the version the research linked to White matter microstructure (tract mean) Anterior limb of internal capsule (L1). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to White matter microstructure (tract mean) Anterior limb of internal capsule (L1). That is a smaller link than two copies.
G/GNo copy of the version the research linked to White matter microstructure (tract mean) Anterior limb of internal capsule (L1). This is the starting point the study compared everyone against.
Science advances · 2025 · PMID 39854466 · open access
Questions about rs17281188
What is rs17281188?
rs17281188 is a single position in the genome, in or near the SLC38A5 gene. Published research associates it with white matter microstructure (tract mean) anterior limb of internal capsule (l1). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs17281188 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs17281188 come from?
GWAS Catalog, Science advances 2025, PMID:39854466. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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White matter microstructure (tract mean) Anterior limb of internal capsule (L1) (rs17281188). MyGeneLog™. https://www.mygenelog.com/variants/rs17281188