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Urinary metabolites

SLC6A20 · rs17279437

Where this position leads

Condition: Urinary Metabolites

What the study found

Who was studied 862 European ancestry male individuals; replicated in 1,862 European ancestry individuals.

The effect The reported allele is A; the catalogue records no effect size ; p = 3 × 10⁻¹⁹.

How common The A allele had a frequency of about 12% in the people studied.

Where it sits Chromosome 3, band 3p21.31 — a missense change in SLC6A20.

What ClinVar records

Classification Benign for Hyperglycinuria, SLC6A20-related disorder; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 6 submitters), last evaluated 2021-05-05. ClinVar record 4845 NM_020208.4(SLC6A20):c.596C>T (p.Thr199Met)

What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

A/A Two copies of the version the research linked to Urinary metabolites. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/G One copy of the version the research linked to Urinary metabolites. That is a smaller link than two copies.

G/G No copy of the version the research linked to Urinary metabolites. This is the starting point the study compared everyone against.

Source

A genome-wide association study of metabolic traits in human urine

Suhre K, Wallaschofski H, Raffler J, Friedrich N, Haring R, Michael K, Wasner C, Krebs A, Kronenberg F, Chang D, Meisinger C, Wichmann HE

and 12 more — show all

Hoffmann W, Völzke H, Völker U, Teumer A, Biffar R, Kocher T, Felix SB, Illig T, Kroemer HK, Gieger C, Römisch-Margl W, Nauck M

Nature genetics · 2011 · PMID 21572414

Questions about rs17279437

What is rs17279437?

rs17279437 is a single position in the genome, in or near the SLC6A20 gene. Published research associates it with urinary metabolites. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs17279437 linked to?

On MyGeneLog this position is linked to Urinary Metabolites. The research behind each link, and its sources, are set out on that condition page.

Does having rs17279437 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs17279437 come from?

GWAS Catalog, Nat Genet 2011, PMID:21572414. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Urinary metabolites (rs17279437). MyGeneLog™. https://www.mygenelog.com/variants/rs17279437

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