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Psoriasis

ELMO1 · rs17259252

Where this position leads

Condition: Psoriasis

rs17259252 Condition: Psoriasis Psoriasis Condition rs17259252 rs17259252 ELMO1

What the study found

Who was studied 26,279 European ancestry cases, 442,230 European ancestry controls, 2,590 South Asian ancestry cases, 1,720 South Asian ancestry controls.

The effect Each copy of the A allele shifted the measure 0.0724 lower (95% confidence interval 0.04-0.105); p = 1 × 10−11.

Where it sits Chromosome 7, band 7p14.1 — in the 5′ untranslated region of ELMO1.

What each result means

A/A Two copies of the version the research linked to Psoriasis. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Psoriasis. That is a smaller link than two copies.
G/G No copy of the version the research linked to Psoriasis. This is the starting point the study compared everyone against.
Source

Questions about rs17259252

What is rs17259252?

rs17259252 is a single position in the genome, in or near the ELMO1 gene. Published research associates it with psoriasis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs17259252 linked to?

On MyGeneLog this position is linked to Psoriasis. The research behind each link, and its sources, are set out on that condition page.

Does having rs17259252 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs17259252 come from?

GWAS Catalog, Journal of translational medicine 2025, PMID:39885523. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Psoriasis (rs17259252). MyGeneLog™. https://www.mygenelog.com/variants/rs17259252

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