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Who was studied 9,365 European or unknown ancestry cases, 946,368 European or unknown ancestry controls; replicated in 13,258 European, African, Admixed American or unknown ancestry cases, 1,435,287 European, African, Admixed American or unknown ancestry controls.
The effect
Each copy of the A allele shifted the measure 0.134 higher; p = 1 × 10−17.
How common The A allele had a frequency of about 20% in the people studied.
Where it sits Chromosome 3, band 3p25.1 — between genes, 34.4 kb from LSM3.
What each result means
A/ATwo copies of the version the research linked to Dilated cardiomyopathy. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Dilated cardiomyopathy. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Dilated cardiomyopathy. This is the starting point the study compared everyone against.
Nature genetics · 2024 · PMID 39572784 · open access
Questions about rs17226476
What is rs17226476?
rs17226476 is a single position in the genome, in or near the near LSM3 gene. Published research associates it with dilated cardiomyopathy. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs17226476 linked to?
On MyGeneLog this position is linked to Dilated Cardiomyopathy. The research behind each link, and its sources, are set out on that condition page.
Does having rs17226476 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs17226476 come from?
GWAS Catalog, Nature genetics 2024, PMID:39572784. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 1242114Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI4Microsoft · Copilot0Amazon2Apple1China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others4Total12Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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