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Hippocampal volume

MSRB3 · rs17178006

What the study found

Who was studied 9,232 European ancestry individuals; replicated in 2,318 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 124 mm3 lower (95% confidence interval 86.76-160.84); p = 5 × 10−11.

How common The G allele had a frequency of about 10% in the people studied.

Where it sits Chromosome 12, band 12q14.3 — in an intron of MSRB3.

What each result means

G/G Two copies of the version the research linked to Hippocampal volume. That is the strongest link of the three results. A link in a study is not a diagnosis.
G/T One copy of the version the research linked to Hippocampal volume. That is a smaller link than two copies.
T/T No copy of the version the research linked to Hippocampal volume. This is the starting point the study compared everyone against.
Source

What people read about alongside this

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs17178006

What is rs17178006?

rs17178006 is a single position in the genome, in or near the MSRB3 gene. Published research associates it with hippocampal volume. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What do people read about alongside rs17178006?

Subjects that appear in the title or abstract of the same papers as this rsID include blood sugar and insulin (1 papers), brain and memory (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs17178006 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs17178006 come from?

GWAS Catalog, Nat Genet 2012, PMID:22504421. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Hippocampal volume (rs17178006). MyGeneLog™. https://www.mygenelog.com/variants/rs17178006

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