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Age at natural menopause or uterine leiomyomata (pleiotropy)

MPPED2 · rs1717777

What the study found

Who was studied 35,474 European ancestry uterine leiomyomata cases, 267,505 European ancestry controls, 201,323 European ancestry individuals with age at natural menopause measurements.

The effect The reported allele is A; the catalogue records no effect size ; p = 4 × 10−12.

Where it sits Chromosome 11, band 11p14.1 — inside MPPED2.

What each result means

A/A Two copies of the version the research linked to Age at natural menopause or uterine leiomyomata (pleiotropy). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/T One copy of the version the research linked to Age at natural menopause or uterine leiomyomata (pleiotropy). That is a smaller link than two copies.
T/T No copy of the version the research linked to Age at natural menopause or uterine leiomyomata (pleiotropy). This is the starting point the study compared everyone against.
Source

Questions about rs1717777

What is rs1717777?

rs1717777 is a single position in the genome, in or near the MPPED2 gene. Published research associates it with age at natural menopause or uterine leiomyomata (pleiotropy). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs1717777 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1717777 come from?

GWAS Catalog, American journal of obstetrics and gynecology 2024, PMID:38191017. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Age at natural menopause or uterine leiomyomata (pleiotropy) (rs1717777). MyGeneLog™. https://www.mygenelog.com/variants/rs1717777

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