C10orf90 · rs17155120
Where this position leads
Condition: Tuberculosis
What the study found
Who was studied 185 Vietnamese ancestry uninfected cases, 353 Vietnamese ancestry infected controls; replicated in 30 uninfected cases, 127 infected controls, 118 South African Coloured uninfected cases, 136 South African Coloured uninfected controls.
The effect Each copy of the T allele carried 0.50 times the odds of Resistance to Mycobacterium tuberculosis infection (95% confidence interval 0.45-0.55); p = 1 × 10−9.
How common The T allele had a frequency of about 20% in the people studied.
Where it sits Chromosome 10, band 10q26.2 — in an intron of C10orf90.
rs17155120 is a single position in the genome, in or near the C10orf90 gene. Published research associates it with resistance to mycobacterium tuberculosis infection. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Tuberculosis. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, PLoS Genet 2021, PMID:33661925. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Resistance to Mycobacterium tuberculosis infection (rs17155120). MyGeneLog™. https://www.mygenelog.com/variants/rs17155120