Lung adenocarcinoma (conditioned on cigarettes per day)
MPZL3 · rs1715422
0 624Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others4Total6Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 13,292 European ancestry cases, 67,596 European ancestry controls, 595 African ancestry cases, 62,112 African ancestry controls; replicated in 7,042 European ancestry cases, 13,599 European ancestry controls, 844 African ancestry cases, 3,779 African ancestry controls.
The effect
Each copy of the T allele carried 0.89 times the odds of Lung adenocarcinoma (conditioned on cigarettes per day) (95% confidence interval 0.863-0.911); p = 3 × 10−18.
How common The T allele had a frequency of about 76% in the people studied.
Where it sits Chromosome 11, band 11q23.3 — in an intron of MPZL3.
What each result means
C/CNo copy of the version the research linked to Lung adenocarcinoma (conditioned on cigarettes per day). This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Lung adenocarcinoma (conditioned on cigarettes per day). That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Lung adenocarcinoma (conditioned on cigarettes per day). That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2024 · PMID 39366959 · open access
Questions about rs1715422
What is rs1715422?
rs1715422 is a single position in the genome, in or near the MPZL3 gene. Published research associates it with lung adenocarcinoma (conditioned on cigarettes per day). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1715422 linked to?
On MyGeneLog this position is linked to EGFR Mutation-Positive Lung Adenocarcinoma. The research behind each link, and its sources, are set out on that condition page.
Does having rs1715422 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1715422 come from?
GWAS Catalog, Nature communications 2024, PMID:39366959. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 624Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others4Total6Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Lung adenocarcinoma (conditioned on cigarettes per day) (rs1715422). MyGeneLog™. https://www.mygenelog.com/variants/rs1715422