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Who was studied 411 Japanese ancestry cases, 2,158 Japanese ancestry controls; replicated in 219 Japanese ancestry cases, 3,770 Japanese ancestry controls.
The effect
Each copy of the C allele carried 1.55 times the odds of Takayasu arteritis (95% confidence interval 1.34-1.80); p = 7 × 10−9.
How common The C allele had a frequency of about 13% in the people studied.
Where it sits Chromosome 14, band 14q11.2 — in the 3′ untranslated region of KLHL33.
What each result means
C/CTwo copies of the version the research linked to Takayasu arteritis. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Takayasu arteritis. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Takayasu arteritis. This is the starting point the study compared everyone against.
Proceedings of the National Academy of Sciences of the United States of America · 2018 · PMID 30498034
Questions about rs1713450
What is rs1713450?
rs1713450 is a single position in the genome, in or near the KLHL33 gene. Published research associates it with takayasu arteritis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1713450 linked to?
On MyGeneLog this position is linked to Takayasu Arteritis. The research behind each link, and its sources, are set out on that condition page.
Does having rs1713450 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1713450 come from?
GWAS Catalog, Proc Natl Acad Sci U S A 2018, PMID:30498034. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
1 32221623115Reads by AI crawlersClaude0ChatGPT2Google · Gemini2Perplexity1Meta AI6Microsoft · Copilot0Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others15Total32Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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