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Gut microbiota (bacterial taxa)

NCAM1 · rs17115310

Where this position leads

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10⁻⁸, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 984 European ancestry individuals; replicated in 530 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 5.53 Z-score lower; p = 3 × 10⁻⁸.

Where it sits Chromosome 11, band 11q23.2 — in an intron of TTC12-DT.

How common each version is

CG

Korean KRGDB

C 99.4% · G 0.6%

Korean Korea4K

C 99.5% · G 0.5%

Korean Korea1K

C 99.5% · G 0.5%

Japanese ToMMo

C 99.8% · G 0.2%

Vietnamese

C 98.6% · G 1.4%

World gnomAD

C 80.8% · G 19.2%

World 1000 Genomes

C 83.2% · G 16.8%

World TOPMed

C 80.6% · G 19.4%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

C/C No copy of the version the research linked to Gut microbiota (bacterial taxa). This is the starting point the study compared everyone against.

C/G One copy of the version the research linked to Gut microbiota (bacterial taxa). That is a smaller link than two copies.

G/G Two copies of the version the research linked to Gut microbiota (bacterial taxa). That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

The effect of host genetics on the gut microbiome

Bonder MJ, Kurilshikov A, Tigchelaar EF, Mujagic Z, Imhann F, Vila AV, Deelen P, Vatanen T, Schirmer M, Smeekens SP, Zhernakova DV, Jankipersadsing SA

and 18 more — show all

Jaeger M, Oosting M, Cenit MC, Masclee AA, Swertz MA, Li Y, Kumar V, Joosten L, Harmsen H, Weersma RK, Franke L, Hofker MH, Xavier RJ, Jonkers D, Netea MG, Wijmenga C, Fu J, Zhernakova A

Nature genetics · 2016 · PMID 27694959

Questions about rs17115310

What is rs17115310?

rs17115310 is a single position in the genome, in or near the NCAM1 gene. Published research associates it with gut microbiota (bacterial taxa). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs17115310 linked to?

On MyGeneLog this position is linked to Gut Microbiota. The research behind each link, and its sources, are set out on that condition page.

Does having rs17115310 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs17115310 come from?

GWAS Catalog, Nat Genet 2016, PMID:27694959. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Gut microbiota (bacterial taxa) (rs17115310). MyGeneLog™. https://www.mygenelog.com/variants/rs17115310

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