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Neuroticism

RPS6KL1 · rs17102884

Where this position leads

Condition: Neuroticism

rs17102884 Condition: Neuroticism Neuroticism Condition rs17102884 rs17102884 RPS6KL1

What the study found

Who was studied 329,821 European ancestry individuals; replicated in 122,867 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 6.6 lower; p = 4 × 10−11.

How common The T allele had a frequency of about 31% in the people studied.

Where it sits Chromosome 14, band 14q24.3 — in an intron of RPS6KL1.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Neuroticism — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Neuroticism.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Neuroticism compared to the general population.
Source

Questions about rs17102884

What is rs17102884?

rs17102884 is a single position in the genome, in or near the RPS6KL1 gene. Published research associates it with neuroticism. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs17102884 linked to?

On MyGeneLog this position is linked to Neuroticism. The research behind each link, and its sources, are set out on that condition page.

Does having rs17102884 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs17102884 come from?

GWAS Catalog, Nature genetics 2018, PMID:29255261. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Neuroticism (rs17102884). MyGeneLog™. https://www.mygenelog.com/variants/rs17102884

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