Sensitive

Cancer of prostate (PheCode 185)

ESR2 · rs17101673

Where this position leads

Condition: Prostate Cancer

rs17101673 Condition: Prostate Cancer Prostate Cancer Condition rs17101673 rs17101673 ESR2

What the study found

Who was studied 15,097 African American or Afro-Caribbean cases, 88,327 African American or Afro-Caribbean controls, 3,485 Hispanic or Latin American cases, 49,682 Hispanic or Latin American controls, 306 East Asian ancestry cases, 5,753 East Asian ancestry controls, 42,997 European ancestry cases, 368,045 European ancestry controls.

The effect Each copy of the A allele shifted the measure 0.147 lower (95% confidence interval 0.12-0.18); p = 9 × 10−15.

How common The A allele had a frequency of about 97% in the people studied.

Where it sits Chromosome 14, band 14q23.2 — in an intron of ESR2.

What ClinVar records

Classification Benign; criteria provided, single submitter (1 of 4 stars, 1 submitter), last evaluated 2018-07-10. ClinVar record 1296189 NM_182914.3(SYNE2):c.12840+79A>G

What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

A/A Two copies of the version the research linked to Cancer of prostate (PheCode 185). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Cancer of prostate (PheCode 185). That is a smaller link than two copies.
G/G No copy of the version the research linked to Cancer of prostate (PheCode 185). This is the starting point the study compared everyone against.
Source

Questions about rs17101673

What is rs17101673?

rs17101673 is a single position in the genome, in or near the ESR2 gene. Published research associates it with cancer of prostate (phecode 185). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs17101673 linked to?

On MyGeneLog this position is linked to Prostate Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs17101673 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs17101673 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Cancer of prostate (PheCode 185) (rs17101673). MyGeneLog™. https://www.mygenelog.com/variants/rs17101673

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