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Who was studied 47,745 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.0476 lower (95% confidence interval 0.034-0.062); p = 5 × 10−13.
How common The A allele had a frequency of about 20% in the people studied.
Where it sits Chromosome 14, band 14q32.13 — in an intron of SYNE3.
What each result means
A/ATwo copies of the version the research linked to TCL1A protein levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to TCL1A protein levels. That is a smaller link than two copies.
G/GNo copy of the version the research linked to TCL1A protein levels. This is the starting point the study compared everyone against.
Nature genetics · 2025 · PMID 39789286 · open access
Questions about rs17092581
What is rs17092581?
rs17092581 is a single position in the genome, in or near the SYNE3 gene. Published research associates it with tcl1a protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs17092581 linked to?
On MyGeneLog this position is linked to Celiac Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs17092581 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs17092581 come from?
GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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TCL1A protein levels (rs17092581). MyGeneLog™. https://www.mygenelog.com/variants/rs17092581