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Corneal resistance factor

near LINC01416 · rs17089989

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 76,029 white-British ancestry individuals; replicated in 10,130 non white-British ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.0704 higher (95% confidence interval 0.048-0.093); p = 4 × 10⁻¹¹.

How common The G allele had a frequency of about 81% in the people studied.

Where it sits Chromosome 18, band 18q21.2 — between genes, 10 kb from LINC01416.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Corneal resistance factor — no copies of the reported risk allele.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Corneal resistance factor.

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Corneal resistance factor compared to the general population.

Source

Fine-mapping and cell-specific enrichment at corneal resistance factor loci prioritize candidate causal regulatory variants

Jiang X, Dellepiane N, Pairo-Castineira E, Boutin T, Kumar Y, Bickmore WA, Vitart V

Communications biology · 2020 · PMID 33311554 · open access

Questions about rs17089989

What is rs17089989?

rs17089989 is a single position in the genome, in or near the near LINC01416 gene. Published research associates it with corneal resistance factor. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs17089989 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs17089989 come from?

GWAS Catalog, Communications biology 2020, PMID:33311554. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Corneal resistance factor (rs17089989). MyGeneLog™. https://www.mygenelog.com/variants/rs17089989

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