Alzheimer disease in high polygenic risk score (>65th percentile)
PAN3 · rs17086376
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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 3,180 European ancestry cases, 978 European ancestry controls.
The effect
Each copy of the T allele carried 0.21 times the odds of Alzheimer disease in high polygenic risk score (>65th percentile) (95% confidence interval 0.122111478957053-0.365709498168588); p = 3 × 10−8.
Where it sits Chromosome 13, band 13q12.2 — in an intron of PAN3.
What each result means
C/CNo copy of the version the research linked to Alzheimer disease in high polygenic risk score (>65th percentile). This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Alzheimer disease in high polygenic risk score (>65th percentile). That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Alzheimer disease in high polygenic risk score (>65th percentile). That is the strongest link of the three results. A link in a study is not a diagnosis.
Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026 · PMID 42557982 · open access
Questions about rs17086376
What is rs17086376?
rs17086376 is a single position in the genome, in or near the PAN3 gene. Published research associates it with alzheimer disease in high polygenic risk score (>65th percentile). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs17086376 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs17086376 come from?
GWAS Catalog, Alzheimer's & dementia : the journal of the Alzheimer's Association 2026, PMID:42557982. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Alzheimer disease in high polygenic risk score (>65th percentile) (rs17086376). MyGeneLog™. https://www.mygenelog.com/variants/rs17086376