Standard

Blood pressure

PLEKHG1 · rs17080102

Where this position leads

What the study found

Who was studied 28,190 African American individuals, 1,188 Nigerian ancestry individuals; replicated in 69,395 European ancestry individuals, 5,266 African American individuals, 6,497 African ancestry individuals, 19,601 East Asian ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.74 lower (95% confidence interval 0.45-1.03); p = 2 × 10⁻¹¹.

How common The C allele had a frequency of about 10% in the people studied.

Where it sits Chromosome 6, band 6q25.1 — in an intron of PLEKHG1.

What each result means

C/C Two copies of the version the research linked to Blood pressure. That is the strongest link of the three results. A link in a study is not a diagnosis.

C/G One copy of the version the research linked to Blood pressure. That is a smaller link than two copies.

G/G No copy of the version the research linked to Blood pressure. This is the starting point the study compared everyone against.

Source

Genome-wide association analysis of blood-pressure traits in African-ancestry individuals reveals common associated genes in African and non-African populations

Franceschini N, Fox E, Zhang Z, Edwards TL, Nalls MA, Sung YJ, Tayo BO, Sun YV, Gottesman O, Adeyemo A, Johnson AD, Young JH

and 94 more — show all

Rice K, Duan Q, Chen F, Li Y, Tang H, Fornage M, Keene KL, Andrews JS, Smith JA, Faul JD, Guangfa Z, Guo W, Liu Y, Murray SS, Musani SK, Srinivasan S, Velez Edwards DR, Wang H, Becker LC, Bovet P, Bochud M, Broeckel U, Burnier M, Carty C, Chasman DI, Ehret G, Chen WM, Chen G, Chen W, Ding J, Dreisbach AW, Evans MK, Guo X, Garcia ME, Jensen R, Keller MF, Lettre G, Lotay V, Martin LW, Moore JH, Morrison AC, Mosley TH, Ogunniyi A, Palmas W, Papanicolaou G, Penman A, Polak JF, Ridker PM, Salako B, Singleton AB, Shriner D, Taylor KD, Vasan R, Wiggins K, Williams SM, Yanek LR, Zhao W, Zonderman AB, Becker DM, Berenson G, Boerwinkle E, Bottinger E, Cushman M, Eaton C, Nyberg F, Heiss G, Hirschhron JN, Howard VJ, Karczewsk KJ, Lanktree MB, Liu K, Liu Y, Loos R, Margolis K, Snyder M, Psaty BM, Schork NJ, Weir DR, Rotimi CN, Sale MM, Harris T, Kardia SL, Hunt SC, Arnett D, Redline S, Cooper RS, Risch NJ, Rao DC, Rotter JI, Chakravarti A, Reiner AP, Levy D, Keating BJ, Zhu X

Asian Genetic Epidemiology Network Consortium

American journal of human genetics · 2013 · PMID 23972371

Questions about rs17080102

What is rs17080102?

rs17080102 is a single position in the genome, in or near the PLEKHG1 gene. Published research associates it with blood pressure. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs17080102 linked to?

On MyGeneLog this position is linked to Blood Pressure. The research behind each link, and its sources, are set out on that condition page.

Does having rs17080102 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs17080102 come from?

GWAS Catalog, Am J Hum Genet 2013, PMID:23972371. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Blood pressure (rs17080102). MyGeneLog™. https://www.mygenelog.com/variants/rs17080102

← See all variants