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Who was studied 8,180 Japanese ancestry cases, 28,612 Japanese ancestry controls; replicated in 3,120 Japanese ancestry cases, 125,064 Japanese ancestry controls, 15,993 European ancestry cases, 113,719 European ancestry controls.
The effect
Each copy of the A allele carried 1.20 times the odds of Atrial fibrillation (95% confidence interval 1.134-1.271); p = 3 × 10−10.
How common The A allele had a frequency of about 8% in the people studied.
Where it sits Chromosome 4, band 4q34.1 — in an intron of HAND2-AS1.
What each result means
A/ATwo copies of the version the research linked to Atrial fibrillation. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Atrial fibrillation. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Atrial fibrillation. This is the starting point the study compared everyone against.
rs17059534 is a single position in the genome, in or near the HAND2 gene. Published research associates it with atrial fibrillation. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs17059534 linked to?
On MyGeneLog this position is linked to Atrial Fibrillation. The research behind each link, and its sources, are set out on that condition page.
Does having rs17059534 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs17059534 come from?
GWAS Catalog, Nat Genet 2017, PMID:28416822. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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