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Sensitive

Metastasis in stage I-III microsatellite instability low/stable colorectal cancer (time to event)

SGCD · rs17053011

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10−7, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 379 European ancestry cases.

The effect Each copy of the T allele carried 6.45 times the odds of Metastasis in stage I-III microsatellite instability low/stable colorectal cancer (time to event) (95% confidence interval 3.29-12.64); p = 5 × 10−8.

Where it sits Chromosome 5, band 5q33.2 — in an intron of SGCD.

How common each version is

GT
Korean KRGDB
G 76.6% · T 23.4%
Korean Korea4K
G 76.0% · T 24.0%
Japanese ToMMo
G 80.1% · T 19.9%
Vietnamese
G 80.4% · T 19.6%
World gnomAD
G 86.8% · T 13.2%
World 1000 Genomes
G 83.3% · T 16.7%
World TOPMed
G 86.0% · T 14.0%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

G/G No copy of the version the research linked to Metastasis in stage I-III microsatellite instability low/stable colorectal cancer (time to event). This is the starting point the study compared everyone against.
G/T One copy of the version the research linked to Metastasis in stage I-III microsatellite instability low/stable colorectal cancer (time to event). That is a smaller link than two copies.
T/T Two copies of the version the research linked to Metastasis in stage I-III microsatellite instability low/stable colorectal cancer (time to event). That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
A genome-wide association study identifies single nucleotide polymorphisms associated with time-to-metastasis in colorectal cancer
Penney ME, Parfrey PS, Savas S, Yilmaz YE
BMC cancer · 2019 · PMID 30738427 · open access

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Metastasis in stage I-III microsatellite instability low/stable colorectal cancer (time to event) (rs17053011). MyGeneLog™. https://www.mygenelog.com/variants/rs17053011

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