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Hepatocellular carcinoma in post hepatitis C eradication by interferon therapy

TLL1 · rs17047200

Where this position leads

Condition: Liver Cancer Risk After Hepatitis C Is Cured

rs17047200 Condition: Liver Cancer Risk After Hepatitis C Is Cured Liver Cancer Risk After Hepatitis C… Condition rs17047200 rs17047200 TLL1

What the study found

Who was studied 123 Japanese ancestry hepatocellular carcinoma cases, 333 Japanese ancestry 5-yr hepatocellular carcinoma-free controls; replicated in 130 Japanese ancestry hepatocellular carcinoma cases, 210 Japanese ancestry 5-yr hepatocellular carcinoma-free controls.

The effect Each copy of the T allele carried 2.37 times the odds of Hepatocellular carcinoma in post hepatitis C eradication by interferon therapy (95% confidence interval 1.74-3.23); p = 3 × 10−8.

Where it sits Chromosome 4, band 4q32.3 — in an intron of TLL1.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Hepatocellular carcinoma in post hepatitis C eradication by interferon therapy — no copies of the reported risk allele.
A/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Hepatocellular carcinoma in post hepatitis C eradication by interferon therapy.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Hepatocellular carcinoma in post hepatitis C eradication by interferon therapy compared to the general population.
Source
Genome-Wide Association Study Identifies TLL1 Variant Associated With Development of Hepatocellular Carcinoma After Eradication of Hepatitis C Virus Infection
Matsuura K, Sawai H, Ikeo K, Ogawa S, Iio E, Isogawa M, Shimada N, Komori A, Toyoda H, Kumada T, Namisaki T, Yoshiji H
and 34 more — show all
Sakamoto N, Nakagawa M, Asahina Y, Kurosaki M, Izumi N, Enomoto N, Kusakabe A, Kajiwara E, Itoh Y, Ide T, Tamori A, Matsubara M, Kawada N, Shirabe K, Tomita E, Honda M, Kaneko S, Nishina S, Suetsugu A, Hiasa Y, Watanabe H, Genda T, Sakaida I, Nishiguchi S, Takaguchi K, Tanaka E, Sugihara J, Shimada M, Kondo Y, Kawai Y, Kojima K, Nagasaki M, Tokunaga K, Tanaka Y
Japanese Genome-Wide Association Study Group for Viral Hepatitis
Gastroenterology · 2017 · PMID 28163062

Questions about rs17047200

What is rs17047200?

rs17047200 is a single position in the genome, in or near the TLL1 gene. Published research associates it with hepatocellular carcinoma in post hepatitis c eradication by interferon therapy. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs17047200 linked to?

On MyGeneLog this position is linked to Liver Cancer Risk After Hepatitis C Is Cured. The research behind each link, and its sources, are set out on that condition page.

Does having rs17047200 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs17047200 come from?

GWAS Catalog, Gastroenterology 2017, PMID:28163062. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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