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Who was studied 11,157 European ancestry cases, 36,699 European ancestry controls, 1,142 African American cases, 2,380 African American controls, 199 Korean ancestry cases, 6,741 Korean ancestry controls, 52 Hispanic cases, 548 Hispanic controls.; replicated in 12,051 European ancestry cases, 11,111 European ancestry controls, 153 Korean ancestry cases, 205 Korean ancestry controls..
The effect
The reported allele is C; the catalogue records no effect size
; p = 3 × 10−10.
How common The C allele had a frequency of about 94% in the people studied.
Where it sits Chromosome 4, band 4q24 — in an intron of ARHGEF38.
What each result means
C/CTwo copies of the version the research linked to Chronic obstructive pulmonary disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Chronic obstructive pulmonary disease. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Chronic obstructive pulmonary disease. This is the starting point the study compared everyone against.
rs17035917 is a single position in the genome, in or near the ARHGEF38 gene. Published research associates it with chronic obstructive pulmonary disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs17035917 linked to?
On MyGeneLog this position is linked to Chronic Obstructive Pulmonary Disease (COPD). The research behind each link, and its sources, are set out on that condition page.
Does having rs17035917 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs17035917 come from?
GWAS Catalog, Nature genetics 2017, PMID:28166215. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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