Standard
Cortical surface area
near RPL9P5 · rs170239
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 33,992 European ancestry individuals; replicated in 14,727 European ancestry individuals, 2,943 individuals.
The effect
Each copy of the T allele shifted the measure 5.71 lower (95% confidence interval 3.94-7.48); p = 3 × 10−10.
How common The T allele had a frequency of about 44% in the people studied.
Where it sits Chromosome 14, band 14q23.1 — between genes, 33.4 kb from RPL9P5.
What each result means
C/C
Published research associates this genotype with typical/baseline likelihood of Cortical surface area — no copies of the reported risk allele.
C/T
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Cortical surface area.
T/T
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Cortical surface area compared to the general population.
Source
The genetic architecture of the human cerebral cortex
Grasby KL,
Jahanshad N,
Painter JN,
Colodro-Conde L,
Bralten J,
Hibar DP,
Lind PA,
Pizzagalli F,
Ching CRK,
McMahon MAB,
Shatokhina N,
Zsembik LCP
and 348 more — show all
Thomopoulos SI,
Zhu AH,
Strike LT,
Agartz I,
Alhusaini S,
Almeida MAA,
Alnæs D,
Amlien IK,
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de Araujo TK,
de Zubicaray GI,
de Zwarte SMC,
den Braber A,
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Ehrlich S,
Engelbrecht HR,
Erk S,
Fan CC,
Fedko IO,
Foley SF,
Ford JM,
Fukunaga M,
Garrett ME,
Ge T,
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Goldman AL,
Green MJ,
Groenewold NA,
Grotegerd D,
Gurholt TP,
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Harrison MB,
Haswell CC,
Hauser M,
Herms S,
Heslenfeld DJ,
Ho NF,
Hoehn D,
Hoffmann P,
Holleran L,
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Janowitz D,
Jansen IE,
Jia T,
Jockwitz C,
Kanai R,
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Kaufmann T,
Kelly S,
Kikuchi M,
Klein M,
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Knodt AR,
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Jang M,
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Mather KA,
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Mayoral Van Son J,
McEwen SC,
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Nordvik JE,
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Cahn W,
Cairns MJ,
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Cavalleri GL,
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Corvin A,
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Science (New York, N.Y.) · 2020 · PMID 32193296
Questions about rs170239
What is rs170239?
rs170239 is a single position in the genome, in or near the near RPL9P5 gene. Published research associates it with cortical surface area. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs170239 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs170239 come from?
GWAS Catalog, Science (New York, N.Y.) 2020, PMID:32193296. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Cortical surface area (rs170239). MyGeneLog™. https://www.mygenelog.com/variants/rs170239
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