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Bone mineral density

CLDN14 · rs170183

Where this position leads

What the study found

Who was studied 5,833 European ancestry females, 2,639 European ancestry males, 784 Han Chinese ancestry females, 763 Han Chinese ancestry males, 712 African American females, 409 Hispanic females; replicated in 7,010 European ancestry females, 3,772 European ancestry males, 2,980 East Asian ancestry females, 2,159 East Asian ancestry males.

The effect Each copy of the G allele shifted the measure 1.92 higher; p = 4 × 10⁻⁹.

How common The G allele had a frequency of about 53% in the people studied.

Where it sits Chromosome 21, band 21q22.13 — in an intron of CLDN14.

What each result means

A/A No copy of the version the research linked to Bone mineral density. This is the starting point the study compared everyone against.

A/G One copy of the version the research linked to Bone mineral density. That is a smaller link than two copies.

G/G Two copies of the version the research linked to Bone mineral density. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Multistage genome-wide association meta-analyses identified two new loci for bone mineral density

Zhang L, Choi HJ, Estrada K, Leo PJ, Li J, Pei YF, Zhang Y, Lin Y, Shen H, Liu YZ, Liu Y, Zhao Y

and 44 more — show all

Zhang JG, Tian Q, Wang YP, Han Y, Ran S, Hai R, Zhu XZ, Wu S, Yan H, Liu X, Yang TL, Guo Y, Zhang F, Guo YF, Chen Y, Chen X, Tan L, Zhang L, Deng FY, Deng H, Rivadeneira F, Duncan EL, Lee JY, Han BG, Cho NH, Nicholson GC, McCloskey E, Eastell R, Prince RL, Eisman JA, Jones G, Reid IR, Sambrook PN, Dennison EM, Danoy P, Yerges-Armstrong LM, Streeten EA, Hu T, Xiang S, Papasian CJ, Brown MA, Shin CS, Uitterlinden AG, Deng HW

Human molecular genetics · 2014 · PMID 24249740

Questions about rs170183

What is rs170183?

rs170183 is a single position in the genome, in or near the CLDN14 gene. Published research associates it with bone mineral density. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs170183 linked to?

On MyGeneLog this position is linked to Heel Bone Mineral Density. The research behind each link, and its sources, are set out on that condition page.

Does having rs170183 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs170183 come from?

GWAS Catalog, Human molecular genetics 2014, PMID:24249740. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Bone mineral density (rs170183). MyGeneLog™. https://www.mygenelog.com/variants/rs170183

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