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Fagerstrӧm test for nicotine dependence

CHRNA5 · rs16969968

Where this position leads

Condition: Smoking Behaviour and Nicotine Dependence

rs16969968 Condition: Smoking Behaviour and Nicotine Dependence Smoking Behaviour and Nicotine Dependence Condition rs16969968 rs16969968 CHRNA5

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Fagerstrӧm test for nicotine dependence — no copies of the reported risk allele.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Fagerstrӧm test for nicotine dependence.
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Fagerstrӧm test for nicotine dependence compared to the general population.
Source
Genome-Wide Meta-Analyses of FTND and TTFC Phenotypes
Chen J, Loukola A, Gillespie NA, Peterson R, Jia P, Riley B, Maes H, Dick DM, Kendler KS, Damaj MI, Miles MF, Zhao Z
and 34 more — show all
Li MD, Vink JM, Minica CC, Willemsen G, Boomsma DI, Qaiser B, Madden PAF, Korhonen T, Jousilahti P, Hällfors J, Gelernter J, Kranzler HR, Sherva R, Farrer L, Maher B, Vanyukov M, Taylor M, Ware JJ, Munafò MR, Lutz SM, Hokanson JE, Gu F, Landi MT, Caporaso NE, Hancock DB, Gaddis NC, Baker TB, Bierut LJ, Johnson EO, Chenoweth M, Lerman C, Tyndale R, Kaprio J, Chen X
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2020 · PMID 31294817

Questions about rs16969968

What is rs16969968?

rs16969968 is a single position in the genome, in or near the CHRNA5 gene. Published research associates it with fagerstrӧm test for nicotine dependence. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs16969968 linked to?

On MyGeneLog this position is linked to Smoking Behaviour and Nicotine Dependence. The research behind each link, and its sources, are set out on that condition page.

Does having rs16969968 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs16969968 come from?

GWAS Catalog, Nicotine Tob Res 2019, PMID:31294817. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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