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Hip shape mode 7

near FBN1 · rs16960886

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10⁻⁷, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 38,175 European ancestry individuals, 5,310 East Asian ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.07 lower (95% confidence interval 0.05-0.09); p = 5 × 10⁻⁸.

How common The A allele had a frequency of about 9% in the people studied.

Where it sits Chromosome 15, band 15q21.1 — between genes, 1 kb from FBN1.

How common each version is

AG

Korean KRGDB

A 3.4% · G 96.7%

Korean Korea4K

A 3.1% · G 96.9%

Japanese ToMMo

A 3.3% · G 96.7%

World gnomAD

A 10.7% · G 89.3%

World 1000 Genomes

A 9.5% · G 90.5%

World TOPMed

A 11.1% · G 88.9%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

A/A Two copies of the version the research linked to Hip shape mode 7. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/G One copy of the version the research linked to Hip shape mode 7. That is a smaller link than two copies.

G/G No copy of the version the research linked to Hip shape mode 7. This is the starting point the study compared everyone against.

Source

The genetic architecture of hip shape and its role in the development of hip osteoarthritis and fracture

Faber BG, Frysz M, Zheng J, Lin H, Flynn KA, Ebsim R, Saunders FR, Beynon R, Gregory JS, Aspden RM, Harvey NC, Lindner C

and 7 more — show all

Cootes T, Evans DM, Davey Smith G, Gao X, Wang S, Kemp JP, Tobias JH

Human molecular genetics · 2025 · PMID 39574169 · open access

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Hip shape mode 7 (rs16960886). MyGeneLog™. https://www.mygenelog.com/variants/rs16960886

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