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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 215,551 European ancestry individuals, 57,332 African American individuals, 24,743 Hispanic individuals; replicated in Up to 319,677 individuals.
The effect
Each copy of the A allele shifted the measure 0.0508 mg dl-1 higher (95% confidence interval 0.035-0.067); p = 3 × 10−10.
How common The A allele had a frequency of about 4% in the people studied.
Where it sits Chromosome 16, band 16q22.1 — in an intron of VPS4A.
What each result means
A/ATwo copies of the version the research linked to HDL cholesterol. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to HDL cholesterol. That is a smaller link than two copies.
G/GNo copy of the version the research linked to HDL cholesterol. This is the starting point the study compared everyone against.
Nature genetics · 2018 · PMID 30275531 · open access
Questions about rs16958751
What is rs16958751?
rs16958751 is a single position in the genome, in or near the VPS4A gene. Published research associates it with hdl cholesterol. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs16958751 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs16958751 come from?
GWAS Catalog, Nature genetics 2018, PMID:30275531. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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