PBX2 · rs169504
Where this position leads
Condition: Anxiety Disorder
What the study found
Who was studied at least 23,606 European ancestry cases, at least 113,351 European ancestry controls; replicated in 624,615 European ancestry cases, 1,310,854 European ancestry controls.
The effect Each copy of the C allele shifted the measure 0.0335 higher (95% confidence interval 0.027-0.04); p = 5 × 10−28.
How common The C allele had a frequency of about 15% in the people studied.
Where it sits Chromosome 6, band 6p21.32 — in the 3′ untranslated region of PBX2.
rs169504 is a single position in the genome, in or near the PBX2 gene. Published research associates it with anxiety. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Anxiety Disorder. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nature human behaviour 2021, PMID:33859377. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Anxiety (rs169504). MyGeneLog™. https://www.mygenelog.com/variants/rs169504