Sensitive

Marginal zone lymphoma or rheumatoid arthritis

FBXW8 · rs16947122

Where this position leads

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Marginal zone lymphoma or rheumatoid arthritis compared to the general population.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Marginal zone lymphoma or rheumatoid arthritis.

T/T Published research associates this genotype with typical/baseline likelihood of Marginal zone lymphoma or rheumatoid arthritis — no copies of the reported risk allele.

Source

Genetic overlap between autoimmune diseases and non-Hodgkin lymphoma subtypes

Din L, Sheikh M, Kosaraju N, Smedby KE, Bernatsky S, Berndt SI, Skibola CF, Nieters A, Wang S, McKay JD, Cocco P, Maynadié M

and 80 more — show all

Foretová L, Staines A, Mack TM, de Sanjosé S, Vyse TJ, Padyukov L, Monnereau A, Arslan AA, Moore A, Brooks-Wilson AR, Novak AJ, Glimelius B, Birmann BM, Link BK, Stewart C, Vajdic CM, Haioun C, Magnani C, Conti DV, Cox DG, Casabonne D, Albanes D, Kane E, Roman E, Muzi G, Salles G, Giles GG, Adami HO, Ghesquières H, De Vivo I, Clavel J, Cerhan JR, Spinelli JJ, Hofmann J, Vijai J, Curtin K, Costenbader KH, Onel K, Offit K, Teras LR, Morton L, Conde L, Miligi L, Melbye M, Ennas MG, Liebow M, Purdue MP, Glenn M, Southey MC, Din M, Rothman N, Camp NJ, Wong Doo N, Becker N, Pradhan N, Bracci PM, Boffetta P, Vineis P, Brennan P, Kraft P, Lan Q, Severson RK, Vermeulen RCH, Milne RL, Kaaks R, Travis RC, Weinstein SJ, Chanock SJ, Ansell SM, Slager SL, Zheng T, Zhang Y, Benavente Y, Taub Z, Madireddy L, Gourraud PA, Oksenberg JR, Cozen W, Hjalgrim H, Khankhanian P

Genetic epidemiology · 2019 · PMID 31407831

Questions about rs16947122

What is rs16947122?

rs16947122 is a single position in the genome, in or near the FBXW8 gene. Published research associates it with marginal zone lymphoma or rheumatoid arthritis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs16947122 linked to?

On MyGeneLog this position is linked to Rheumatoid Arthritis. The research behind each link, and its sources, are set out on that condition page.

Does having rs16947122 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs16947122 come from?

GWAS Catalog, Genet Epidemiol 2019, PMID:31407831. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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