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Who was studied 133,653 European ancestry individuals; replicated in 50,074 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.13 lower; p = 4 × 10−27.
How common The T allele had a frequency of about 3% in the people studied.
Where it sits Chromosome 15, band 15q26.1 — a synonymous change in ACAN.
What ClinVar records
ClassificationBenign for Spondyloepimetaphyseal dysplasia, aggrecan type, Short stature and advanced bone age, with or without early-onset osteoarthritis and/or osteochondritis dissecans, Spondyloepiphyseal dysplasia, Kimberley type; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 7 submitters), last evaluated 2026-05-09.
ClinVar record 1206376NM_001369268.1(ACAN):c.1221C>T (p.Val407=)
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
C/CNo copy of the version the research linked to Height. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Height. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Height. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs16942341 is a single position in the genome, in or near the ACAN gene. Published research associates it with height. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs16942341 linked to?
On MyGeneLog this position is linked to Height. The research behind each link, and its sources, are set out on that condition page.
Does having rs16942341 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs16942341 come from?
GWAS Catalog, Nature 2010, PMID:20881960. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 3142182239Reads by AI crawlersClaude4ChatGPT2Google · Gemini0Perplexity1Meta AI8Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)0Others9Total31Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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