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Sex hormone-binding globulin levels

CUX2 · rs16941230

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

2 / 4

Its strongest genetic-study result is p = 10−27, with 3 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 310,323 European ancestry individuals, 5,523 African ancestry individuals, 6,638 South Asian ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.0735 higher (95% confidence interval 0.06-0.087); p = 2 × 10−27.

Where it sits Chromosome 12, band 12q24.11 — in an intron of CUX2.

How common each version is

AC
Korean KRGDB
A 99.7% · C 0.3%
Korean Korea4K
A 99.6% · C 0.4%
Korean Korea1K
A 99.7% · C 0.3%
Japanese ToMMo
A 99.9% · C 0.1%
Vietnamese
A 98.1% · C 1.9%
World gnomAD
A 96.0% · C 4.0%
World 1000 Genomes
A 96.3% · C 3.7%
World TOPMed
A 96.1% · C 3.9%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

A/A No copy of the version the research linked to Sex hormone-binding globulin levels. This is the starting point the study compared everyone against.
A/C One copy of the version the research linked to Sex hormone-binding globulin levels. That is a smaller link than two copies.
C/C Two copies of the version the research linked to Sex hormone-binding globulin levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Genetics of 35 blood and urine biomarkers in the UK Biobank
Sinnott-Armstrong N, Tanigawa Y, Amar D, Mars N, Benner C, Aguirre M, Venkataraman GR, Wainberg M, Ollila HM, Kiiskinen T, Havulinna AS, Pirruccello JP
and 11 more — show all
Qian J, Shcherbina A, Rodriguez F, Assimes TL, Agarwala V, Tibshirani R, Hastie T, Ripatti S, Pritchard JK, Daly MJ, Rivas MA
FinnGen
Nature genetics · 2021 · PMID 33462484 · open access

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Sex hormone-binding globulin levels (rs16941230). MyGeneLog™. https://www.mygenelog.com/variants/rs16941230

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