Retinal thickness (functional principal component 3)
SOX5 · rs16926921
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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 43,150 European ancestry individuals; replicated in 1,179 Central or South Asian individuals, 1,161 African ancestry individuals.
The effect
Each copy of the C allele shifted the measure 19.4 higher (95% confidence interval 13.64-25.22); p = 5 × 10−11.
How common The C allele had a frequency of about 25% in the people studied.
Where it sits Chromosome 12, band 12p12.1 — in an intron of SOX5.
What each result means
A/ANo copy of the version the research linked to Retinal thickness (functional principal component 3). This is the starting point the study compared everyone against.
A/COne copy of the version the research linked to Retinal thickness (functional principal component 3). That is a smaller link than two copies.
C/CTwo copies of the version the research linked to Retinal thickness (functional principal component 3). That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2025 · PMID 39904976 · open access
Questions about rs16926921
What is rs16926921?
rs16926921 is a single position in the genome, in or near the SOX5 gene. Published research associates it with retinal thickness (functional principal component 3). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs16926921 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs16926921 come from?
GWAS Catalog, Nature communications 2025, PMID:39904976. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
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Retinal thickness (functional principal component 3) (rs16926921). MyGeneLog™. https://www.mygenelog.com/variants/rs16926921