Sensitive

Allergic disease (asthma, hay fever or eczema)

JAK2 · rs16922576

Where this position leads

Condition: Asthma

rs16922576 Condition: Asthma Asthma Condition rs16922576 rs16922576 JAK2

What the study found

Who was studied 180,129 European ancestry cases, 180,709 European ancestry controls.

The effect Each copy of the C allele carried 1.04 times the odds of Allergic disease (asthma, hay fever or eczema) (95% confidence interval 1.03-1.05); p = 3 × 10−10.

How common The C allele had a frequency of about 32% in the people studied.

Where it sits Chromosome 9, band 9p24.1 — in an intron of JAK2.

What each result means

C/C Two copies of the version the research linked to Allergic disease (asthma, hay fever or eczema). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Allergic disease (asthma, hay fever or eczema). That is a smaller link than two copies.
T/T No copy of the version the research linked to Allergic disease (asthma, hay fever or eczema). This is the starting point the study compared everyone against.
Source

Questions about rs16922576

What is rs16922576?

rs16922576 is a single position in the genome, in or near the JAK2 gene. Published research associates it with allergic disease (asthma, hay fever or eczema). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs16922576 linked to?

On MyGeneLog this position is linked to Asthma. The research behind each link, and its sources, are set out on that condition page.

Does having rs16922576 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs16922576 come from?

GWAS Catalog, Nature genetics 2017, PMID:29083406. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Allergic disease (asthma, hay fever or eczema) (rs16922576). MyGeneLog™. https://www.mygenelog.com/variants/rs16922576

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