Sensitive

Response to risperidone in schizophrenia

SLC1A1 · rs16921385

Where this position leads

Condition: Schizophrenia

rs16921385 Condition: Schizophrenia Schizophrenia Condition rs16921385 rs16921385 SLC1A1

What the study found

Who was studied 425 Han Chinese ancestry cases; replicated in 559 Han Chinese ancestry cases.

The effect Each copy of the A allele shifted the measure 6.8 higher (95% confidence interval 4.37-9.23); p = 4 × 10−8.

Where it sits Chromosome 9, band 9p24.2 — in an intron of SLC1A1.

What each result means

A/A Two copies of the version the research linked to Response to risperidone in schizophrenia. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Response to risperidone in schizophrenia. That is a smaller link than two copies.
G/G No copy of the version the research linked to Response to risperidone in schizophrenia. This is the starting point the study compared everyone against.
Source

Questions about rs16921385

What is rs16921385?

rs16921385 is a single position in the genome, in or near the SLC1A1 gene. Published research associates it with response to risperidone in schizophrenia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs16921385 linked to?

On MyGeneLog this position is linked to Schizophrenia. The research behind each link, and its sources, are set out on that condition page.

Does having rs16921385 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs16921385 come from?

GWAS Catalog, Lancet Psychiatry 2018, PMID:29503163. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Response to risperidone in schizophrenia (rs16921385). MyGeneLog™. https://www.mygenelog.com/variants/rs16921385

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