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Weight

near PTCH1 · rs16909923

Where this position leads

Condition: Obesity and Body Weight

rs16909923 Condition: Obesity and Body Weight Obesity and Body Weight Condition rs16909923 rs16909923 near PTCH1

What the study found

Who was studied 165,419 East Asian ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.0224 higher (95% confidence interval 0.015-0.029); p = 4 × 10−10.

How common The G allele had a frequency of about 17% in the people studied.

Where it sits Chromosome 9, band 9q22.32 — between genes, 4.7 kb from PTCH1.

What each result means

A/A No copy of the version the research linked to Weight. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Weight. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Weight. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
A cross-population atlas of genetic associations for 220 human phenotypes
Sakaue S, Kanai M, Tanigawa Y, Karjalainen J, Kurki M, Koshiba S, Narita A, Konuma T, Yamamoto K, Akiyama M, Ishigaki K, Suzuki A
and 34 more — show all
Suzuki K, Obara W, Yamaji K, Takahashi K, Asai S, Takahashi Y, Suzuki T, Shinozaki N, Yamaguchi H, Minami S, Murayama S, Yoshimori K, Nagayama S, Obata D, Higashiyama M, Masumoto A, Koretsune Y, Ito K, Terao C, Yamauchi T, Komuro I, Kadowaki T, Tamiya G, Yamamoto M, Nakamura Y, Kubo M, Murakami Y, Yamamoto K, Kamatani Y, Palotie A, Rivas MA, Daly MJ, Matsuda K, Okada Y
FinnGen
Nature genetics · 2021 · PMID 34594039

Questions about rs16909923

What is rs16909923?

rs16909923 is a single position in the genome, in or near the near PTCH1 gene. Published research associates it with weight. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs16909923 linked to?

On MyGeneLog this position is linked to Obesity and Body Weight. The research behind each link, and its sources, are set out on that condition page.

Does having rs16909923 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs16909923 come from?

GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Weight (rs16909923). MyGeneLog™. https://www.mygenelog.com/variants/rs16909923

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