Gene Knowledge Graph
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Sensitive

Skin cancer

RGS22 · rs16897870

Where this position leads

Condition: Sun Sensitivity, Freckling and Skin Cancer Risk

rs16897870 Condition: Sun Sensitivity, Freckling and Skin Cancer Risk Sun Sensitivity, Freckling and Skin… Condition rs16897870 rs16897870 RGS22

What the study found

Who was studied 431 African American or Afro-Caribbean cases, 55,074 African American or Afro-Caribbean controls, 55,282 European ancestry cases, 260,386 European ancestry controls, 979 Hispanic or Latin American cases, 28,335 Hispanic or Latin American controls.

The effect Each copy of the C allele shifted the measure 0.0691 higher (95% confidence interval 0.047-0.091); p = 4 × 10−11.

How common The C allele had a frequency of about 83% in the people studied.

Where it sits Chromosome 8, band 8q22.2 — in an intron of RGS22.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Skin cancer compared to the general population.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Skin cancer.
T/T Published research associates this genotype with typical/baseline likelihood of Skin cancer — no copies of the reported risk allele.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs16897870

What is rs16897870?

rs16897870 is a single position in the genome, in or near the RGS22 gene. Published research associates it with skin cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs16897870 linked to?

On MyGeneLog this position is linked to Sun Sensitivity, Freckling and Skin Cancer Risk. The research behind each link, and its sources, are set out on that condition page.

Does having rs16897870 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs16897870 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Skin cancer (rs16897870). MyGeneLog™. https://www.mygenelog.com/variants/rs16897870

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