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Its strongest genetic-study result is p = 10−22, with 5 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied Up to 182,413 European ancestry females.
The effect
Each copy of the G allele shifted the measure 0.04 higher (95% confidence interval 0.028-0.052); p = 3 × 10−10.
How common The G allele had a frequency of about 38% in the people studied.
Where it sits Chromosome 6, band 6p22.1 — in an intron of POLR1HASP.
How common each version is
AG
KoreanKRGDB
A 57.4% · G 42.6%
KoreanKorea4K
A 57.6% · G 42.4%
Japanese ToMMo
A 64.1% · G 35.9%
Vietnamese
A 65.0% · G 35.0%
World gnomAD
A 64.7% · G 35.3%
World 1000 Genomes
A 62.2% · G 37.8%
The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.
What each result means
A/ANo copy of the version the research linked to Menarche (age at onset). This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Menarche (age at onset). That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Menarche (age at onset). That is the strongest link of the three results. A link in a study is not a diagnosis.
rs16896742 is a single position in the genome, in or near the HLA-A gene. Published research associates it with menarche (age at onset). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs16896742 linked to?
On MyGeneLog this position is linked to Age at Menarche. The research behind each link, and its sources, are set out on that condition page.
Does having rs16896742 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs16896742 come from?
GWAS Catalog, Nature 2014, PMID:25231870. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license
Menarche (age at onset) (rs16896742). MyGeneLog™. https://www.mygenelog.com/variants/rs16896742