SLC45A2 · rs16891982
Where this position leads
Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.
What ClinVar records
Classification
Benign for Oculocutaneous albinism type 4, SKIN/HAIR/EYE PIGMENTATION 5, BLACK/NONBLACK HAIR; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 7 submitters), last evaluated 2026-02-04.
ClinVar record 197829 NM_016180.5(SLC45A2):c.1122G>C (p.Leu374Phe)
Classification
Benign for SKIN/HAIR/EYE PIGMENTATION 5, BLACK/NONBLACK HAIR, Malignant melanoma of skin; criteria provided, single submitter (1 of 4 stars, 3 submitters), last evaluated 2026-02-04.
ClinVar record 4505 NM_016180.5(SLC45A2):c.1122= (p.Leu374=)
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What people read about alongside this
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
rs16891982 is a single position in the genome, in or near the SLC45A2 gene. Published research associates it with skin pigmentation. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Sun Sensitivity, Freckling and Skin Cancer Risk. The research behind each link, and its sources, are set out on that condition page.
Subjects that appear in the title or abstract of the same papers as this rsID include skin, sun and hair (15 papers), natural selection (3 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Guenther et al. 2014, Human Molecular Genetics — SLC45A2 and human skin pigmentation variation. PMID 24880339. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Skin pigmentation (rs16891982). MyGeneLog™. https://www.mygenelog.com/variants/rs16891982