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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 3,247 European ancestry individuals, 600 African ancestry individuals, 151 East Asian ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.44 higher (95% confidence interval 0.36-0.51); p = 8 × 10−20.
How common The A allele had a frequency of about 5% in the people studied.
Where it sits Chromosome 6, band 6p21.32 — in an intron of NOTCH4.
What each result means
A/ATwo copies of the version the research linked to Complement C4 levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Complement C4 levels. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Complement C4 levels. This is the starting point the study compared everyone against.
Journal of the American Society of Nephrology : JASN · 2021 · PMID 33941608
Questions about rs16869834
What is rs16869834?
rs16869834 is a single position in the genome, in or near the C4 gene. Published research associates it with complement c4 levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs16869834 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs16869834 come from?
GWAS Catalog, Journal of the American Society of Nephrology : JASN 2021, PMID:33941608. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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