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Who was studied 23,151 European ancestry cases, 553,439 European ancestry controls, 2,261 African American cases, 49,400 African American controls, 654 Hispanic cases, 21,214 Hispanic controls; replicated in 17,672 cases, 167,295 controls.
The effect
Each copy of the C allele carried 1.06 times the odds of Venous thromboembolism (95% confidence interval 1.04-1.09); p = 3 × 10−10.
How common The C allele had a frequency of about 32% in the people studied.
Where it sits Chromosome 5, band 5p13.1 — in an intron of OSMR-DT.
What each result means
C/CTwo copies of the version the research linked to Venous thromboembolism. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Venous thromboembolism. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Venous thromboembolism. This is the starting point the study compared everyone against.
Nature genetics · 2019 · PMID 31676865 · open access
Questions about rs16867574
What is rs16867574?
rs16867574 is a single position in the genome, in or near the RP11-122C5.1 gene. Published research associates it with venous thromboembolism. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs16867574 linked to?
On MyGeneLog this position is linked to Venous Thromboembolism. The research behind each link, and its sources, are set out on that condition page.
Does having rs16867574 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs16867574 come from?
GWAS Catalog, Nat Genet 2019, PMID:31676865. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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