Breakthrough COVID-19 susceptibility after at least one dose of a COVID-19 vaccine
ST6GAL1 · rs16861415
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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 74,662 European ancestry cases, 240,661 European ancestry controls.
The effect
Each copy of the C allele carried 0.84 times the odds of Breakthrough COVID-19 susceptibility after at least one dose of a COVID-19 vaccine (95% confidence interval 0.82-0.86); p = 7 × 10−55.
How common The C allele had a frequency of about 8% in the people studied.
Where it sits Chromosome 3, band 3q27.3 — in an intron of ST6GAL1.
What each result means
C/CTwo copies of the version the research linked to Breakthrough COVID-19 susceptibility after at least one dose of a COVID-19 vaccine. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Breakthrough COVID-19 susceptibility after at least one dose of a COVID-19 vaccine. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Breakthrough COVID-19 susceptibility after at least one dose of a COVID-19 vaccine. This is the starting point the study compared everyone against.
Nature communications · 2024 · PMID 39384777 · open access
Questions about rs16861415
What is rs16861415?
rs16861415 is a single position in the genome, in or near the ST6GAL1 gene. Published research associates it with breakthrough covid-19 susceptibility after at least one dose of a covid-19 vaccine. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs16861415 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs16861415 come from?
GWAS Catalog, Nature communications 2024, PMID:39384777. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Breakthrough COVID-19 susceptibility after at least one dose of a COVID-19 vaccine (rs16861415). MyGeneLog™. https://www.mygenelog.com/variants/rs16861415